Melanopsin-mediated pupil function is impaired in Parkinson’s disease
نویسندگان
چکیده
منابع مشابه
Intrinsically photosensitive retinal ganglion cell mediated pupil function is impaired in Parkinson's disease
26 Parkinson’s disease is characterised by non-motor symptoms including sleep and circadian 27 disruption, but the underlying aetiology is not well understood. Melanopsin-expressing 28 intrinsically photosensitive Retinal Ganglion Cells (ipRGC) transmit light signals from the 29 eye to brain areas controlling circadian rhythms and the pupil light reflex. Here we evaluate 30 the hypothesis that ...
متن کاملMelanopsin-mediated post-illumination pupil response in the peripheral retina.
Intrinsically photosensitive retinal ganglion cells (ipRGCs) regulate pupil size by integrating extrinsic rod and cone signals with intrinsic melanopsin-mediated phototransduction. Light adapted pupil diameter is determined by the corneal flux density (CFD), and for central visual field stimulation the melanopsin-mediated post-illumination pupil response (PIPR) follows this same CFD relationshi...
متن کاملMelanopsin-Mediated Post-Illumination Pupil Response in Early Age-Related Macular Degeneration.
PURPOSE To determine whether melanopsin-expressing intrinsically photosensitive retinal ganglion cell (ipRGC) inputs to the pupil light reflex (PLR) are affected in early age-related macular degeneration (AMD). METHODS The PLR was measured in 40 participants (20 early AMD and 20 age-matched controls) using a custom-built Maxwellian view pupillometer. Sinusoidal stimuli (0.5 Hz, 11.9 seconds d...
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Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR). Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ...
متن کاملMelanopsin- and L-cone–induced pupil constriction is inhibited by S- and M-cones in humans
The human retina contains five photoreceptor types: rods; short (S)-, mid (M)-, and long (L)-wavelength-sensitive cones; and melanopsin-expressing ganglion cells. Recently, it has been shown that selective increments in M-cone activation are paradoxically perceived as brightness decrements, as opposed to L-cone increments. Here we show that similar effects are also observed in the pupillary lig...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-26078-0